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“The joy of discovery is certainly the liveliest that the mind of man can ever feel”

- Claude Bernard -

Journal Publications

  1. Saxton MW, Perry BW, Hutzenbiler BDE, Trojahn S, Gee A, Brown AP, Merrihew GE, Park J, Cornejo OE, MacCoss MJ, Robbins CT, Jansen HT, Kelley JL. Serum plays an important role in reprogramming the seasonal transcriptional profile of brown bear adipocytes. 2022 iScience (ACCEPTED FOR PUBLICATION).

  2. Wang RJ, Peña-Garcia Y, Bibby M, Raveendran M, Harris RA, Jansen HT, Robbins CT, Rogers J, Kelley JL, Hahn MW. Hibernation shows no apparent effect on germline mutation rates in grizzly bears; Genome Biol. and Evol. 2022; 14(10): 00:1-12.

  3. Armstrong EE, Perry BW, Huang Y, Garimella KV, Jansen HT, Robbins CT, Tucker NR, Kelley JL. A beary good genome: Haplotype-resolved, chromosome-level assembly of the brown bear (Ursus arctos); Genome Biol. Evol. 2022; 14(9): 00:1-9.

  4. Tseng E, Underwood J, Hutzenbiler BE, Trojahn S, Kingham B, Shevchenko O, Bernberg E, Robbins C, Jansen H, Kelley J.  Long-read isoform sequencing reveals tissue-specific isoform expression between active and hibernating brown bears (Ursus arctos). G3 Genes Genomes Genetics. 2022; 12(3):00:1-10.

  5. Perry BW, Armstrong EE, Robbins CT, Jansen HT, Kelley JL. Temporal analysis of gene expression and isoform switching in brown bears (Ursus arctos). Integ. Comp. Biol. 2022;

  6. Hogan HHR, Hutzenbiler BE, Robbins CT, Jansen HT.  Changing lanes: Seasonal differences in cellular metabolism of adipocytes in grizzly bears (Ursus arctos horribilis). J. Comp. Physiol. B. 2022 192:397-410.

  7. Jansen HT, Evans Hutzenbiler BD, Hapner HR, McPhee ML, Carnahan T, Kelley JL, Saxton M, Robbins CT. Can offsetting the energetic cost of hibernation restore an active season phenotype in grizzly bears (Ursus arctos horribilis). J. Exp. Biol. 2021: 224(12): 00:1-11;

  8. Cattet M, Janz DM, Kapronczai L, Erlenbach J, Jansen HT, Nelson OL, Robbins CT, Stenhouse GB. Cortisol levels in blood and hair of unanesthetized grizzly bears (Ursus arctos) following intravenous cosyntropin injection. Vet Med Sci. 2021: 00:1-7.
  9. ​Ware JV, Rode KA, Robbins CT, Leise T, Weil CR, Jansen HT. The clock continues ticking in polar bears: circadian rhythmicity of free ranging polar bears. J. Biol. Rhythms. 2020; 35(2):180-194.

  10. Vella, CA, Nelson OL, Jansen HT, Robbins CT, Jensen AE, Constantinescu S, Abbott MJ, Turcotte LP. Regulation of metabolism during hibernation in brown bears (Ursus arctos): involvement of cortisol, PGC-1α and AMPK in adipose tissue and skeletal muscle. Comp. Biochem. Physiol., Part A. 2020; 240:110591.

  11. Wright HL, Chen AV, Jansen HT. Composition of Cerebrospinal Fluid in Clinically Normal Grizzly Bears (Ursus Arctos Horribilis). J Zoo Wildlife Med. 2019;50(3):739-741.

  12. Jansen HT, Trojahn S, Saxton MW, Quackenbush CR, Evans Hutzenbiler BD, Nelson OL, Cornejo OE, Robbins CT, Kelley JL. Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear. Commun Biol. 2019; 2:336.

  13. Ware JV, Rode KD, Bromaghin JF, Douglas DC, Wilson RR, Regehr EV, Amstrup SC, Durner GM, Pagano AM, Olson J, Robbins CT, Jansen HT. Habitat degradation affects the summer activity of polar bears. Oecologia. 2017;184(1):87-99.

  14. Rivet DR, Nelson OL, Vella CA, Jansen HT, Robbins CT. Systemic effects of a high saturated fat diet in grizzly bears (Ursus arctos horribilis). Canadian Journal of Zoology. 2017;95(11):797-807.

  15. Rigano KS, Gehring JL, Hutzenbiler BDE, Chen AV, Nelson OL, Vella CA, Robbins CT, Jansen HT. Life in the fat lane: seasonal regulation of insulin sensitivity, food intake, and adipose biology in brown bears. Journal of Comparative Physiology B-Biochemical Systems and Environmental Physiology. 2017;187(4):649-676.

  16. Cattet M, Stenhouse GB, Janz DM, Kapronczai L, Erlenbach JA, Jansen HT, Nelson OL, Robbins CT, Boulanger J. The quantification of reproductive hormones in the hair of captive adult brown bears and their application as indicators of sex and reproductive state. Conservation Physiology. 2017;5.

  17. Joyce-Zuniga NM, Newberry RC, Robbins CT, Ware JV, Jansen HT, Nelson OL. Positive Reinforcement Training for Blood Collection in Grizzly Bears (Ursus arctos horribilis) Results in Undetectable Elevations in Serum Cortisol Levels: A Preliminary Investigation. J Appl Anim Welf Sci. 2016;19(2):210-215.

  18. Jansen HT, Leise T, Stenhouse G, Pigeon K, Kasworm W, Teisberg J, Radandt T, Dallmann R, Brown S, Robbins CT. The bear circadian clock doesn't 'sleep' during winter dormancy. Front Zool. 2016;13.

  19. Guo R, Simasko SM, Jansen HT. Chronic Alcohol Consumption in Rats Leads to Desynchrony in Diurnal Rhythms and Molecular Clocks. Alcoholism-Clinical and Experimental Research. 2016;40(2):291-300.

  20. Gehring JL, Rigano KS, Hutzenbiler BDE, Nelson OL, Robbins CT, Jansen HT. A protocol for the isolation and cultivation of brown bear (Ursus arctos) adipocytes. Cytotechnology. 2016;68(5):2177-2191.

  21. Ware JV, Rode KD, Pagano AM, Bromaghin J, Robbins CT, Erlenbach J, Jensen S, Cutting A, Nicassio-Hiskey N, Hash A, Owen M, Jansen HT. Validation of mercury tip-switch and accelerometer activity sensors for identifying resting and active behavior in bears. Ursus. 2015;26(2):86-96.

  22. Kissler JL, Sirohi S, Reis DJ, Jansen HT, Quock RM, Smith DG, Walker BM. The One-Two Punch of Alcoholism: Role of Central Amygdala Dynorphins/Kappa-Opioid Receptors. Biological psychiatry. 2014;75(10):774-782.

  23. Guo R, Jansen HT, Simasko SM. Chronic Alcohol Consumption Alters the Molecular Clock of the Hypothalamic-Pituitary-Adrenal Axis at Peripheral but Not Central Sites. Alcoholism-Clinical and Experimental Research. 2014;38:151a-151a.

  24. Browning JR, Jansen HT, Sorg BA. Inactivation of the paraventricular thalamus abolishes the expression of cocaine conditioned place preference in rats. Drug Alcohol Depen. 2014;134:387-390.

  25. Wiater MF, Li AJ, Dinh TT, Jansen HT, Ritter S. Leptin-sensitive neurons in the arcuate nucleus integrate activity and temperature circadian rhythms and anticipatory responses to food restriction. Am J Physiol-Reg I. 2013;305(8):R949-R960.

  26. Ware JV, Nelson OL, Robbins CT, Carter PA, Sarver BAJ, Jansen HT. Endocrine rhythms in the brown bear (Ursus arctos): Evidence supporting selection for decreased pineal gland size. Physiol. Rep. 2013; 1(3): e00048.

  27. Jackson LM, Mytinger A, Roberts EK, Lee TM, Foster DL, Padmanabhan V, Jansen HT. Developmental Programming: Postnatal Steroids Complete Prenatal Steroid Actions to Differentially Organize the GnRH Surge Mechanism and Reproductive Behavior in Female Sheep. Endocrinology. 2013;154(4):1612-1623.

  28. Fortin JK, Ware JV, Jansen HT, Schwartz CC, Robbins CT. Temporal niche switching by grizzly bears but not American black bears in Yellowstone National Park. J. Mammal. 2013;94(4):833-844.

  29. Ware JV, Nelson OL, Robbins CT, Jansen HT. Split Parturition Observed in a Captive North American Brown Bear (Ursus arctos). Zoo Biol. 2012;31(2):255-259.

  30. Ware JV, Nelson OL, Robbins CT, Jansen HT. Temporal organization of activity in the brown bear (Ursus arctos): roles of circadian rhythms, light, and food entrainment. Am J Physiol-Reg I. 2012;303(9):R890-R902.

  31. Li AJ, Wiater MF, Oostrom MT, Smith BR, Wang Q, Dinh TT, Roberts BL, Jansen HT, Ritter S. Leptin-sensitive neurons in the arcuate nuclei contribute to endogenous feeding rhythms. Am J Physiol-Reg I. 2012;302(11):R1313-R1326.

  32. Jansen HT, Sergeeva A, Stark G, Sorg BA. Circadian Discrimination of Reward: Evidence for Simultaneous Yet Separable Food-and Drug-Entrained Rhythms in the Rat. Chronobiol Int. 2012;29(4):454-468.

  33. Bilimoria JL, Reis DJ, Nealey KA, Jansen HT, Smith DG, Walker BM. Chronic Alcohol Increases Central Amygdala Dynorphin and Induces Escalated Self-Administration That Is Rescued by Kappa-Opioid Receptor Blockade. Alcoholism-Clinical and Experimental Research. 2012;36:267a-267a.

  34. Sorg BA, Stark G, Sergeeva A, Jansen HT. Photoperiodic Suppression of Drug Reinstatement. Neuroscience. 2011;176:284-295.

  35. Jansen HT, Hershey J, Mytinger A, Foster DL, Padmanabhan V. Developmental Programming: Reproductive Endocrinopathies in the Adult Female Sheep After Prenatal Testosterone Treatment Are Reflected in Altered Ontogeny of GnRH Afferents. Endocrinology. 2011;152(11):4288-4297.

  36. Hileman SM, McManus CJ, Goodman RL, Jansen HT. Neurons of the Lateral Preoptic Area/Rostral Anterior Hypothalamic Area Are Required for Photoperiodic Inhibition of Estrous Cyclicity in Sheep. Biology of Reproduction. 2011;85(5):1057-1065.

  37. Browning JR, Browning DA, Maxwell AO, Dong Y, Jansen HT, Panksepp J, Sorg BA. Positive affective vocalizations during cocaine and sucrose self-administration: A model for spontaneous drug desire in rats. Neuropharmacology. 2011;61(1-2):268-275.

  38. Goodman RL, Jansen HT, Billings HJ, Coolen LM, Lehman MN. Neural Systems Mediating Seasonal Breeding in the Ewe. Journal of Neuroendocrinology. 2010;22(7):674-681.

  39. Bass CE, Jansen HT, Roberts DCS. Free-Running Rhythms of Cocaine Self-Administration in Rats Held under Constant Lighting Conditions. Chronobiol Int. 2010;27(3):535-548.

  40. Sergeeva A, Jansen HT. Neuroanatomical Plasticity in the Gonadotropin-Releasing Hormone System of the Ewe: Seasonal Variation in Glutamatergic and gamma-Aminobutyric Acidergic Afferents. Journal of Comparative Neurology. 2009;515(6):615-628.

  41. Sleipness EP, Jansen HT, Schenk JO, Sorg BA. Time-of-Day Differences in Dopamine Clearance in the Rat Medial Prefrontal Cortex and Nucleus Accumbens. Synapse. 2008;62(12):877-885.

  42. Sleipness EP, Sorg BA, Jansen HT. Diurnal differences in dopamine transporter and tyrosine hydroxylase levels in rat brain: Dependence on the suprachiasmatic nucleus. Brain Research. 2007;1129(1):34-42.

  43. Sleipness EP, Sorg BA, Jansen HT. Contribution of the suprachiasmatic nucleus to day: night variation in cocaine-seeking behavior. Physiology & Behavior. 2007;91(5):523-530.

  44. Jansen HT, Kirby JD, Cooke PS, Arambepola N, Iwamoto GA. Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus. Physiology & Behavior. 2007;90(5):771-781.

  45. Sleipness EP, Sorg BA, Jansen HT. Time of day alters long-term sensitization to cocaine in rats. Brain Research. 2005;1065(1-2):132-137.

  46. Jansen HT, Cutter C, Hardy S, Lehman MN, Goodman RL. Seasonal plasticity within the gonadotropin-releasing hormone (GnRH) system of the ewe: Changes in identified GnRH inputs and glial association. Endocrinology. 2003;144(8):3663-3676.

  47. Romeo RD, Wagner CK, Jansen HT, Diedrich SL, Sisk CL. Estradiol induces hypothalamic progesterone receptors but does not activate mating behavior in male hamsters (Mesocricetus auratus) before puberty. Behavioral Neuroscience. 2002;116(2):198-205.

  48. Viguie C, Jansen HT, Glass JD, Watanabe M, Billings HJ, Coolen L, Lehman MN, Karsch FJ. Potential for polysialylated form of neural cell adhesion molecule-mediated neuroplasticity within the gonadotropin-releasing hormone neurosecretory system of the ewe. Endocrinology. 2001;142(3):1317-1324.

  49. Seta KA, Jansen HT, Kreitel KD, Lehman M, Behbehani MM. Cold water swim stress increases the expression of neurotensin mRNA in the lateral hypothalamus and medial preoptic regions of the rat brain. Molecular Brain Research. 2001;86(1-2):145-152.

  50. Jansen HT, West C, Lehman MN, Padmanabhan V. Ovarian estrogen receptor-beta (ERß) regulation: I. Changes in ER beta messenger RNA expression prior to ovulation in the ewe. Biology of Reproduction. 2001;65(3):866-872.

  51. Ying SX, Jansen HT, Lehman MN, Fong SL, Kao WWY. Retinal degeneration in cone photoreceptor cell-ablated transgenic mice. Mol Vis. 2000;6(12):101-108.

  52. Stefanovic I, Adrian B, Jansen HT, Lehman MN, Goodman RL. The ability of estradiol to induce fos expression in a subset of estrogen receptor-alpha-containing neurons in the preoptic area of the ewe depends on reproductive status. Endocrinology. 2000;141(1):190-196.

  53. Fong SL, Ying S, Jansen HT, Lehman MN, Kao WWY. Retinal degeneration and light-induced c-fos mRNA expression in the suprachiasmatic nucleus of cone photoreceptor-ablated transgenic mice. Invest Ophth Vis Sci. 2000;41(4):S202-S202.

  54. Silver R, Sookhoo AI, LeSauter J, Stevens P, Jansen HT, Lehman MN. Multiple regulatory elements result in regional specificity in circadian rhythms of neuropeptide expression in mouse SCN. Neuroreport. 1999;10(15):3165-3174.

  55. Hileman SM, Lubbers LS, Jansen HT, Lehman MN. Changes in hypothalamic estrogen receptor-containing cell numbers in response to feed restriction in the female lamb. Neuroendocrinology. 1999;69(6):430-437.

  56. Coolen LM, Jansen HT, Goodman RL, Wood RI, Lehman MN. A new method for simultaneous demonstration of anterograde and retrograde connections in the brain: co-injections of biotinylated dextran amine and the beta subunit of cholera toxin. J Neurosci Meth. 1999;91(1-2):1-8.

  57. Jansen HT, Iwamoto GA, Jackson GL. Central connections of the ovine olfactory bulb formation identified using wheat germ agglutinin-conjugated horseradish peroxidase. Brain Research Bulletin. 1998;45(1):27-39.

  58. Tian MT, Broxmeyer HE, Fan Y, Lai ZN, Zhang SW, Aronica S, Cooper S, Bigsby RM, Steinmetz R, Engle SJ, Mestek A, Pollock JD, Lehman MN, Jansen HT, Ying MY, Stambrook PJ, Tischfield JA, Yu L. Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice. Journal of Experimental Medicine. 1997;185(8):1517-1522.

  59. Lehman MN, Goodman RL, Karsch FJ, Jackson GL, Berriman SJ, Jansen HT. The GnRH system of seasonal breeders: Anatomy and plasticity. Brain Research Bulletin. 1997;44(4):445-457.

  60. Jansen HT, Lubbers LS, Macchia E, DeGroot LJ, Lehman MN. Thyroid hormone receptor (alpha) distribution in hamster and sheep brain: Colocalization in gonadotropin-releasing hormone and other identified neurons. Endocrinology. 1997;138(11):5039-5047.

  61. Jansen HT, Hileman SM, Lubbers LS, Kuehl DE, Jackson GL, Lehman MN. Identification and distribution of neuroendocrine gonadotropin-releasing hormone neurons in the ewe. Biology of Reproduction. 1997;56(3):655-662.

  62. Lehman MN, Durham DM, Jansen HT, Adrian B, Goodman RL. Dopaminergic A14/A15 neurons are activated during estradiol negative feedback in anestrous, but not breeding season, ewes. Endocrinology. 1996;137(10):4443-4450.

  63. Jansen HT, Urbanski HF, Lehman MN. Thyroxine (T4) acts centrally to attenuate short photoperiod responses in male Syrian hamsters. Biology of Reproduction. 1996;54:149-149.

  64. Jansen HT, Hileman SM, Lubbers LS, Jackson GL, Lehman MN. A subset of estrogen receptor-containing neurons project to the median eminence in the ewe. Journal of Neuroendocrinology. 1996;8(12):921-927.

  65. Scott CJ, Jansen HT, Kao CC, Kuehl DE, Jackson GL. Disruption of Reproductive Rhythms and Patterns of Melatonin and Prolactin Secretion Following Bilateral Lesions of the Suprachiasmatic Nuclei in the Ewe. Journal of Neuroendocrinology. 1995;7(6):429-443.

  66. Keiper GL, Jansen HT, Lehman MN. Tracing Efferents from Anterior Hypothalamic Cell-Suspension Grafts the Use of Xenografts and a Donor-Specific Antibody. Experimental Neurology. 1995;135(2):166-166.

  67. Jansen HT, Hileman SM, Kuehl DE, Lubbers LS, Jackson GL, Lehman MN. Distribution of GnRH Neurons in the Ewe That Project to the Median-Eminence. Biology of Reproduction. 1995;52:155-155.

  68. Durham DM, Jansen HT, Adrian BA, Goodman RL, Lehman MN. Dopaminergic A14/A15 Neurons Are Activated during Estradiol Negative Feedback in the Anestrous Ewe. Biology of Reproduction. 1995;52:156-156.

  69. Lehman MN, Berriman SJ, Jansen HT, Parfitt D, Dahl GE, Evans NP, Karsch FJ. Is Fos Expression in Gnrh and Other Neurons during the Estradiol-Induced Lh Surge of the Ewe Associated with Neurosecretory or Behavioral Events. Biology of Reproduction. 1994;50:185-185.

  70. Jansen HT, Lubbers LS, Degroot LJ, Lehman MN. Colocalization of Alpha-Thyroid Hormone Receptors in Neuropeptide-Containing and Neurotransmitter-Containing Neurons of the Sheep and Hamster Brain. Biology of Reproduction. 1994;50:108-108.

  71. Jansen HT, Gong QZ, Norgren RB, Lehman MN. Single-Label and Double-Label Immunocytochemical Study of the Ovine Suprachiasmatic Nucleus (Scn) - Gabaergic and Peptidergic Relationships. Brain Research Bulletin. 1994;34(5):499-506.

  72. Jansen HT. Single-Label and Double-Label Immunocytochemical Study of the Ovine Suprachiasmatic Nucleus (Scn) - Gabaergic and Peptidergic Relationships (Vol 34, Pg 499, 1994). Brain Research Bulletin. 1994;35(4):393-393.

  73. Hansen LG, Jansen HT. Environmental Estrogens. Science. 1994;266(5185):526.

  74. Jansen HT, Popiela CL, Jackson GL, Iwamoto GA. A Reevaluation of the Effects of Gonadal-Steroids on Neuronal-Activity in the Male-Rat. Brain Research Bulletin. 1993;31(1-2):217-223.

  75. Jansen HT, Jackson GL. Olfactory-Bulb Removal Does Not Prevent Gonadotropin or Prolactin Responses to Changing Photoperiod in the Ewe. Neuroendocrinology. 1993;57(3):448-456.

  76. Jansen HT, Jackson GL. Circannual Rhythms in the Ewe - Patterns of Ovarian Cycles and Prolactin Secretion under 2 Different Constant Photoperiods. Biology of Reproduction. 1993;49(3):627-634.

  77. Jansen HT, Cooke PS, Porcelli J, Liu TC, Hansen LG. Estrogenic and Antiestrogenic Actions of PCBs in the Female Rat - Invitro and In vivo Studies. Reproductive Toxicology. 1993;7(3):237-248.

  78. Jansen HT, Khalid M, Jackson GL. N-Methyl-D, L-Aspartate Induces a Transient Increase in LH-Secretion in the Seasonally Anestrous Ewe. Domest Anim Endocrin. 1991;8(1):55-62.

  79. Jackson GL, Jansen HT. Persistence of a Circannual Rhythm of Plasma Prolactin Concentrations in Ewes Exposed to a Constant Equatorial Photoperiod. Biology of Reproduction. 1991;44(3):469-475.

  80. Jansen HT, Dellinger JA. Comparing the Cardiac Vagolytic Effects of Atropine and Methylatropine in Rhesus Macaques. Pharmacol Biochem Be. 1989;32(1):175-179.

  81. Jackson GL, Jansen HT, Kuehl DE, Shanks RD. Time of the Sidereal Year Affects Responsiveness to the Phase-Resetting Effects of Photoperiod in the Ewe. Journal of Reproduction and Fertility. 1989;85(1):221-227.

  82. Jansen HT, Dellinger JA. Effects of Atropine on Respiratory Sinus Arrhythmia (Rsa) in the Rhesus Macaque. Neurotoxicology and Teratology. 1988;10(2):169-174.

  83. Dellinger JA, Jansen HT, Zaber DJ, Birnbaum SG. Vagal Tone Monitoring - a Potential Indicator of Anti-Cholinesterase Exposure in Macaca-Mulatta. Toxicology. 1988;49(2-3):227-235.

  84. Jeffery EH, Jansen HT, Dellinger JA. Invivo Interactions of Aluminum with Hepatic Cytochrome-P-450 and Metallothionein. Fund Appl Toxicol. 1987;8(4):541-548.


1.   Jansen HT and Lampa S.  Neuroanatomy: A Laboratory Guide. 2nd Edition, 2017.  Top Hat Monocle Corp., Toronto, Ontario, Canada, ISBN 978-1-77330-056-6

2.   Jenny L, Geske N, Jansen HT, Werstein K. Human Anatomy., 2018. Top Hat Monocle Corp., Toronto, Ontario, Canada, ISBN 978-1-77330-097-9.

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